Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2002-02-14
2003-10-07
Webman, Edward J. (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S642000, C514S826000, C514S394000, C514S230800, C514S383000, C424S043000
Reexamination Certificate
active
06630466
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to new medicament compositions based on anticholinergic compounds, which have a long-lasting effect, and salmeterol, processes for their production and their use in the therapy of respiratory ailments.
BACKGROUND OF THE INVENTION
It is known from the prior art that &bgr;-mimetics and anticholinergics can successfully be used as bronchospasmolytics for the treatment of obstructive respiratory ailments, such as, e.g., asthma. Substances with &bgr;-sympatho-mimetic effectiveness, such as, e.g., the active substance formoterol, also known from the prior art, can, however, be associated with undesirable side-effects when administered to humans.
Generally, the central effects manifest as unease, excitation, sleeplessness, fear, shaking fingers, outbreaks of sweating and headaches. Here, inhalative application does not exclude these side-effects although they are generally less severe than with peroral or parenteral application.
The side-effects of the &bgr;-sympatho-mimetics used as asthma agents are primarily associated with a more or less pronounced &bgr;1-stimulating effect on the heart. It generates tachycardia, palpitation, angina pectoris-like complaints and arrhythmia [P. T. Ammon (Ed.), Medicament Side-Effects and Interactions,
Wissenschaftliche Verlagsgesellschaft
, Stuttgart 1986, S. 584].
REFERENCES:
patent: 6433027 (2002-08-01), Bozung et al.
patent: 6455524 (2002-09-01), Bozung et al.
Bozung Karl-Heinz
Pairet Michel
Reichl Richard
Walland Alexander
Boehringer Ingelheim Pharma KG
Bottino Anthony P.
Raymond Robert P.
Webman Edward J.
Witkowski Timothy X.
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