Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-10-07
1999-08-17
Saunders, David
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 435325, 4353201, C07H 2104, C12P 2100, C12N 1512, C12N 510
Patent
active
059395400
ABSTRACT:
Disclosed is a novel protein designated platelet secretory transport protein (PSTP). PSTP occurs in platelets and binds to syntaxin. An isolated DNA encoding PSTP, vectors and cells containing the DNA, and PSTP specific antibodies are also disclosed. A PSTP antibody can be used to target a compound to an activated platelet in a mammal for diagnostic or therapeutic purposes. Also disclosed is an in vitro screening method for identifying a compound that inhibits PSTP-syntaxin binding, and an in vitro method for identifying a compound that inhibits PSTP gene expression.
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President and Fellows of Harvard College
Saunders David
VanderVegt F. Pierre
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