Liquid purification or separation – Processes – Liquid/liquid solvent or colloidal extraction or diffusing...
Reexamination Certificate
2001-06-25
2003-06-24
Kim, John (Department: 1723)
Liquid purification or separation
Processes
Liquid/liquid solvent or colloidal extraction or diffusing...
C210S321690, C210S321710, C210S645000, C210S646000, C210S791000, C210S805000
Reexamination Certificate
active
06582604
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a dialysis system and a method of cleaning and priming a blood circulation path of the dialysis system. More particularly, the invention relates to a dialysis system capable of using a dialysate in place of physiological saline as a replenisher solution when blood pressure is lowered and capable of using a dialysate in place of physiological saline in a cleaning and priming operation and in a blood returning operation in blood dialysis treatment, and relates to a method of cleaning and priming of the dialysis system.
2. Description of the Prior Art
A dialysate is used in blood dialysis. Air or filled sterilized water is contained in a dialyzer before the dialyzer is used in blood dialysis and the air or the sterilized water needs to be removed. Therefore, as a pretreatment, conventionally, the inside of a dialyzer and the inside of a blood line connected to the dialyzer (hereinafter, referred to as the inside of a blood circulation path) are cleaned and primed by using, for example, physiological saline (normally, about 500 through 1000 ml).
Further, after finishing blood dialysis, blood remaining in the inside of the blood circulation path needs to be returned into the body of a patient who has undergone the blood dialysis treatment (referred to as blood returning) as much as possible, and as a post treatment, conventionally, blood is returned into the human body by using, for example, physiological saline (about 300 ml).
However, since physiological saline is expensive, a conventional blood dialysis system using a large volume thereof is problematic because of the considerable cost of the blood dialysis.
Hence, in order to resolve such a drawback, there have been proposed a method and an apparatus of blood dialysis (Japanese Unexamined Patent Publication No. 80346/1996) capable of achieving a reduction in the cost of the blood dialysis by reducing the volume of physiological saline used in the priming and blood returning operations, and a physical solution treating apparatus (Japanese Unexamined Patent Publication No. 150201/1996) capable of using a dialysate in place of physiological saline used in the priming and blood returning operations.
According to the blood dialysis system of Japanese Unexamined Patent Publication No. 80346/1996, when a blood dialysis operation is stopped, dialysate from a dialysate supply source is filtered to clean the dialysate and the provided filtered dialysate is pressurized from a dialysate flow path of a dialyzer to a blood flow path through dialysis membranes constituting a dialysis element. However, according to the method, in respect of blood remaining in a blood circulation path upstream from the blood flow path, the blood needs to be pushed out to the blood flow path by using physiological saline. Thus, despite the improvement, there is a drawback in that a necessary volume of physiological saline needs to be prepared and the operation takes time and labor.
Meanwhile, according to the physical solution treating apparatus of Japanese Unexamined Patent Publication No. 150201/1996, a dialysate reservoir bag is connected to an intermediate point of an artery side line through a branch tube and a dialysate in the dialysate reservoir bag can be transferred to prime a blood chamber and a vein side line through the artery side line. However, according to the method, there are drawbacks in that not only is the dialysate reservoir bag expensive but also an operation of filling the dialysate into the bag becomes necessary and the operation is troublesome.
Further, there is a case in which a replenisher solution (normally, physiological saline is used) is infused into the body of a patient when the blood pressure of the patient is lowered during blood dialysis treatment and in infusing the replenisher solution, conventionally, there are adopted methods, for example, as illustrated in FIG.
7
and FIG.
8
.
According to the method illustrated in
FIG. 7
, a replenisher solution supply source
105
is connected to a blood circulation path
101
and the replenisher solution is infused while stopping the blood dialysis operation. As the replenisher solution supply source
105
, a bottle or a bag filled with sterilized replenisher solution is generally adopted. In replenishing the solution, a valve
106
is closed, a valve
107
is opened and the replenisher solution is infused from the replenisher solution supply source
105
into the blood circulation path
101
by a blood pump
104
. Flow rate of the replenisher solution is determined by the blood pump
104
. Further, in the drawing, numeral
100
designates a dialyzer and numerals
102
and
103
designate drip chambers.
According to the method illustrated in
FIG. 8
, a replenisher solution line
209
is separately provided and a dialysate in a dialysate circulation path
206
which is cleaned by endotoxin filters
207
and
208
is infused into a blood circulation path
201
. The replenisher solution line
209
is provided with an endotoxin filter
211
for further cleaning the dialysate and the replenisher solution is infused by a replenisher solution pump
210
. Further, in the drawing, numeral
200
designates a dialyzer and numeral
205
designates a closed-type water-removal control apparatus.
However, according to the method illustrated in
FIG. 7
, the replenisher solution needs to be prepared, the setup operation of connecting the replenisher solution supply source to the blood line and adding the replenisher solution (the case of a large volume of the replenisher solution) requires additional labor, and there are drawbacks in that there is a danger of erroneous operation or contamination since the replenishing operation is comparatively troublesome and that the cost is considerable.
Meanwhile, according to the method illustrated in
FIG. 8
, the dialysate is infused directly into the blood circulation path and accordingly, two of the endotoxin filters are normally needed and the cost is increased. Further, although the solution needs to be replenished when the blood pressure is lowered, according to the system of
FIG. 8
, water is removed by the dialyzer by a volume of the replenished solution and accordingly, there is a drawback in that the solution cannot be substantially replenished.
SUMMARY OF THE INVENTION
The invention has been carried out in view of the above-described situation and it is an object thereof to provide a dialysis system which does not need to use physiological saline in replenishing a solution or in cleaning and priming the dialysis system, does not need a troublesome setting operation and replenishing of the system can easily and accurately be set with the flow rate of a replenisher solution.
As a result intensive study in view of the above-described situation, the inventors have conceived of a system in which, in a dialysis system having a closed-type water-removal control mechanism, there is provided a pump for infusing water (normally, reverse osmosis (RO) water) to a communication line of a dialysate downstream from a dialyzer and water is pressurized into the communication line of the dialysate as a result of which the dialysate is infused from a side of a dialysate chamber of a dialyzer to a side of a blood chamber thereof, and completed the invention. That is, according to one aspect of the invention, there is provided a method of cleaning and priming a dialysis system which includes a closed-type water-removal control apparatus, a dialysate line, a dialyzer and a blood line wherein a dialysate is made to flow into a blood circulation path through a membrane of the dialyzer by pressurizing water into the closed communication line of the dialysate downstream from the dialyzer. In this case, it is preferable that the dialysis system is a dialysis system for personal use.
Further, according to another aspect of the invention, there is provided a dialysis system comprising a dialyzer having a dialysate flow path and a blood flow path partitioned by a dialysis membrane, a close
Nikaido Taku
Ueda Mistutaka
Kim John
Kubovcik & Kubovcik
Nipro Corporation
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