Transglutaminase cross-linkable polypeptides and methods relatin

Details Transglutaminase cross-linkable polypeptides and methods relatin Transglutaminase cross-linkable polypeptides and methods relatin

1995-06-07

1999-08-17

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 514 21, A61K 3800

Patent

active

059393858

ABSTRACT:
Polypeptides of from about 9-120 amino acid residues comprising a truncated segment of fibrinogen which may be flanked by elastomeric peptides, wherein the polypeptides are cross-linkable by a transglutaminase, homo- and copolymers containing such polypeptides are disclosed. The homo- and co-polymers disclosed herein are useful in tissue sealant and wound healing formulations.

REFERENCES:
patent: 4589882 (1986-05-01), Urry
Melham, "Elastic Fiber Assembly: Macromolecular Interactions" Caplus 1996:372833, 1995.

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