Gel formulations for topical drug delivery

Details Gel formulations for topical drug delivery Gel formulations for topical drug delivery

1996-12-03

1999-08-17

Brouillette, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

514944, A61F 1300

Patent

active

059390905

ABSTRACT:
Pharmaceutical gel formulations for topical drug delivery include drug, colloidal silicon dioxide, triacetin and, preferably, propylene glycol. The gel formulations are well suited for topical delivery of the drug -1-ethanol, which when applied topically induces cytokines, such as interferon and tumor necrosis factor, locally in the skin or mucous membranes of a mammal. The gel formulations are also well-suited for topical delivery of drugs for treatment of diseases involving skin and/or mucosal lesions because the gel formulations do not need to include irritating components.

REFERENCES:
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patent: 4788064 (1988-11-01), Patel
patent: 4814173 (1989-03-01), Song et al.
patent: 4871723 (1989-10-01), Makino
patent: 5238944 (1993-08-01), Wick et al.
patent: 5389640 (1995-02-01), Gerster et al.
patent: 5492911 (1996-02-01), Stief
"3M's Immune Response Enhancers", Pharmoproject Magazine, Sep. 1996.
M. A. Tomai et al., "Immunomodulating and Antiviral Activities of the Imidazoquinoline S-28463", Antiviral Research, 28 (1995) 253-264.
E. Istvan et al., "The Utilization of Colloid Siliciumdioxide in the Pharmaceutical Technology", Pharmacy 19 (1975) 290-296.

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