Prostaglandin I.sub.2 analogues

Details Prostaglandin I.sub.2 analogues Prostaglandin I.sub.2 analogues

1978-02-16

1979-12-11

Ford, John M.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

542429, 26034622, 536103, 424180, A61K 3134, C07D30793

Patent

active

041783670

ABSTRACT:
Prostaglandin I.sub.2 analogues of the formula: ##STR1## (wherein Y represents trans-vinylene or ethylene, R.sup.1 represents hydrogen or an alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents hydrogen, methyl or ethyl, R.sup.3 represents a single bond, or an alkylene group containing from 1 to 4 carbon atoms, R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, each represent hydrogen or an alkyl group containing from 1 to 8 carbon atoms, n represents 3, 4, 5 or 6, the wavy line attached to the carbon atoms in positions 11 and 15 depicted in the formula represents .alpha.- or .beta.-configuration or mixtures thereof, and the double bond between C.sub.6 -C.sub.6 is Z or E) are new compounds possessing pharmacological properties typical of prostaglandins, for example PGI.sub.2.

REFERENCES:
Johnson et al., J. Am. Chem. Soc., 99:12, Jun. 8, 1977, pp. 4182-4184.

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