Process for the preparation of enantiomerically pure imidazolyl

Details Process for the preparation of enantiomerically pure imidazolyl Process for the preparation of enantiomerically pure imidazolyl

1996-10-10

1997-09-02

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483114, 548534, C07D22118, C07D23354

Patent

active

056633432

ABSTRACT:
The invention relates to a method for the preparation of an enantiomerically pure imidazolyl compound of the general formula ##STR1## wherein n is 0 or 1; m is 1 or 2;
R.sub.1 is hydrogen, methyl or ethyl; and
C* denotes a chiral centre;
as well as its pharmaceutically acceptable acid addition salt; by
a) adding a pyroglutamic acid in an optically active form to a solution of a racemic mixture of the above compound I, followed by separation of the crystallized acid addition salt of said mixture of enantiomers of compound I enriched in one enantiomer, from the mother liquor enriched in the other enantiomer
b) when the crystallized acid addition salt is enriched in the undersired enantiomer, by then separating the mixture of enantiomers in the mother liquor from said optically active carboxylic acid, followed by addition of a racemic mixture of said carboxylic acid to a solution of the obtained mixture of isomers of I, and by separation of the crystallized acid addition salt of said mixture, enriched in the desired enantiomer, from the mother liquor, and
(c) optionally recrystallizing the product until the desired enantiomeric purity is obtained, and by then
(d) converting this acid-addition salt of the desired enantiomer to the desired enantiomerically pure imidazolyl compound of the general formula I or to its pharmaceutically acceptable acid addition salt.

REFERENCES:
patent: 4939136 (1990-07-01), Haeck

Affiliated with

Also associated with

Rating

Process for the preparation of enantiomerically pure imidazolyl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of enantiomerically pure imidazolyl , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of enantiomerically pure imidazolyl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-309727