Substituted diaminophthalimides and analogues

Details Substituted diaminophthalimides and analogues Substituted diaminophthalimides and analogues

1995-10-18

1997-09-02

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544296, 544345, 546256, 5483121, 548467, 548472, 548473, 548474, 548475, 548476, C07D40104, C07D40304, C07D20948, C07D24138

Patent

active

056633360

ABSTRACT:
A process for the synthesis of compounds of formula I ##STR1## wherein Ar.sub.1, Ar.sub.2, A.sub.1, A.sub.2, R and X are as defined in the description, exhibit valuable pharmaceutical properties and are effective especially against diseases responsive to the inhibition of protein kinases, for example tumors.

REFERENCES:
patent: 2508418 (1950-05-01), Strain et al.
patent: 2556664 (1951-06-01), Smith et al.
patent: 2995559 (1961-08-01), Ruschig et al.
patent: 3001998 (1961-09-01), Ruschig et al.
patent: 3308135 (1967-03-01), Jansen et al.
patent: 3644405 (1972-02-01), Horstmann et al.
patent: 3857947 (1974-12-01), Teach
patent: 3980634 (1976-09-01), Weaver
patent: 4039522 (1977-08-01), Weaver et al.
patent: 4363917 (1982-12-01), Fischer et al.
House, C. et al., Europ. J. Biochem, 140, 363-367 (1984).
Akiyama, T. et al. Science 232, 1644 (1986).
Davis, et al. Tetrahedron Letters, 31, 5201-4 (1990).
Rosenmund et al., Ber. 52, 1749 (1916.
von Braun et al., Ann 488, 111 (1931).
The Merck Index, 10th edition, Merck & Co., Inc. Rahway, 1983, p. ONR-79.
Wohrle, et al., Synthesis, Feb. 1993, pp. 194-196.
Matlin, et al. J. Chem Res. (M). 1920-1943 (1990).
Cronin et al., Cancer Research, vol. 46, pp. 4701-4705, (Sep. 1986).
Ozawa et al., Int. J. Cancer, vol. 40, pp. 706-710, (1987).
Weissman et al., Cell, vol. 32, pp. 599-606, (Feb. 1983).
Carpenter et al., Analytical Biochem., vol. 153, 279-282 (1985).
Meyer et al., Int J. Cancer, vol. 43, 851-856 (1989).
Matlin et al., J. Chem. Res., (1990) pp. 246-247.
White et al., J. Org. Chem. vol. 32, pp. 1921-1926.
Shephard. J. Chem. Soc. Perkins Trans. I 1495-1498 (1986.

Affiliated with

Also associated with

Rating

Substituted diaminophthalimides and analogues does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted diaminophthalimides and analogues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted diaminophthalimides and analogues will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-309689