Pyran-4-ylmethyl substituted arylalkylaryl-, arylalkenylylaryl-,

Details Pyran-4-ylmethyl substituted arylalkylaryl-, arylalkenylylaryl-, Pyran-4-ylmethyl substituted arylalkylaryl-, arylalkenylylaryl-,

1993-08-24

1996-01-16

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514392, 514454, 544316, 5483111, 549426, A61K 3135, A61K 31495, C07D31500, C07D23904

Patent

active

054847869

ABSTRACT:
Compounds of structure ##STR1## where W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.5 and R.sup.6 are independently selected from hydrogen and alkyl, or R.sup.5 and R.sup.6, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## L.sup.1 and L.sup.2 are independently selected from a valence bond, alkylene, propenylene, and propynylene, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is oxygen, >NR.sup.9 where R.sup.9 is hydrogen or alkyl, or ##STR4## where n=0, 1, or 2, and A is selected from ##STR5## inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

REFERENCES:
Chemical Abstract, vol. 79 No. 105085, Carr et al. 1979, "Antihestamine piperidine derivatives".

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