Semisynthetic ganglioside analogues

Details Semisynthetic ganglioside analogues Semisynthetic ganglioside analogues

1993-07-26

1996-01-16

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 25, 514 53, 514 61, 536 41, 536 53, 536 551, 536 553, 536123, A61K 31715, C07H 504

Patent

active

054847753

ABSTRACT:
N-acyl-N,N'-dilysogangliosides, wherein the acyl groups are derived from unsubstituted aliphatic acids having from 1 to 11 carbon atoms, and N'-acyl-N,N'-dilysogangliosides and N,N'-di-acyl-N,N'-dilysogangliosides, in which the acyl groups are derived from unsubstituted aliphatic acids having from 1 to 24 carbon atoms (with the exception of certain acetyl and diacetyl derivatives). The compounds of the invention exhibit an inhibiting action on protein kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system. Pharmaceutical compositions and therapeutic utilities for the lysoganglioside derivatives are also disclosed.

REFERENCES:
patent: 4476119 (1984-10-01), della Valle et al.
patent: 4593091 (1986-06-01), della Valle et al.
patent: 4713374 (1987-12-01), della Valle et al.
patent: 4716223 (1987-12-01), della Valle et al.
patent: 4990604 (1991-02-01), Ogawa et al.
patent: 5010059 (1991-04-01), Schmidt et al.
patent: 5350841 (1994-09-01), Romeo et al.
J. of Pharm. & Exper. Ther; vol. 252 No., Manev et al.
G. A. Nores et al., Methods in Enzymology, vol. 179 (1989) pp. 242-253.
S. Sonnino et al., Journal of Lipid Research, vol. 26, No. 2 (1985) pp. 248-257.
Y. Hirabayashi et al., J. Bioche., vol. 103, No. 1 (1988) pp. 1-4.
Acta Psychiat. Scand. 55, 102, (1977).
Eur. Medicophys., 13, 1, (1977).
Adv. Exp. Med. Biol. 71, 275 (1976).
Electromyogr. Clin, Neurophysiol. 19, 353, (1979).
Minerva Medica, 69, 3277, (1978).
Minerva Stomat. 27, 177, (1978).
Med. del Lavoro, 68, 296 (1977).
Brain Res. 197, 236, (1980).
J. of Neurochem. 37, 350 (1981).
Glycolipid Methodology, Robert W. Ledeen and Robert K. Yu, pp. 186-215, Chapter IX and X (1976).
Song et al., Biochemistry 28:4194-4200 (1989).
Glycolipid Methodology, Eric G. Brunngraber; Gudio Tettamantio and Bruno Berra; pp. 158-187; Chapter III. (1976).
Neuenhofer et al., Biochemistry 24:525-532 (1985).

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