Hydroxamate inhibitors of endothelin converting enzyme

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.

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548496, A61K 3806

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active

056632967

ABSTRACT:
Hydroxamate compounds of the following formula are disclosed:

REFERENCES:
International Search Report--Corresponding PCT Application PCT/US94/05888 Mailed Oct. 4, 1994.
European Journal of Biochemistry, vol. 150, No.1, Jul. 1985, pp. 135-140.
Molecular Pharmacology, vol. 30, No. 4, Oct. 1986, pp. 338-344.
M. Fujino, et al., "Highly Potent Analogues of Enkephalin" Peptide Chemistry 1979, pp. 205-208.
Biorganic & Medicinal Chemistry Letters, vol. 2, No. 12, 1992, GB, pp. 1685-1690.
Chen, Bioorg Med Chem Lett 2, 1685, 1992.
Abstract 89-210052/29 JO 1146-896-A Fuji Pharm Ind KK FUJY Apr. 12, 1987.

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