Therapeutic amides

Details Therapeutic amides Therapeutic amides

1992-07-23

1993-12-21

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514269, 514369, 514372, 514376, 514380, 514473, 514445, 514255, 544318, 544408, 546294, 548187, 548213, 548228, 548229, 548232, 548243, 549 66, 549475, C07D21375, A61K 3144

Patent

active

052721639

ABSTRACT:
Amides having formula I: ##STR1## wherein E, X, R.sup.2 and R.sup.3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof, which are useful in the treatment of urinary incontinence. Further provided are processes for preparing the amides and pharmaceutical compositions containing them.

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R. Bayles et al., "The Smiles rearrangement of 2-aryloxy-2-methylpropanamides. Synthesis of N-aryl-2-hydroxy-2-methylpropanamides" Synthesis. (1977), 31-33.
G. Edwards et al., "Structure-activity relationships of potassium channel openers", Trends in Pharmacological Sciences. (1990), 11, 417-422.

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