Pyrazolopyrimidinone antianginal agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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544262, 544118, 514258, 514253, A61K 31505

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active

052721477

ABSTRACT:
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof are selective cGMP PDE inhibitors which are useful in the treatment of such diseases and adverse conditions as angina, hypertension, congestive heart failure, reduced blood vessel patency, peripheral vascular disease, stroke, bronchitis, chronic asthma, allergic asthma, allergic rhinitis, glaucoma, and diseases characterized by disorders of gut motility.

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Burger, "Medicinal Chemistry", 2d ed., Interscience, NY, 1960, p. 42.
Tokkyo Koho, Chem. Abstr., vol. 106, Entry 101967h, Abstracting Japan 61-236778 (1986).
Hamilton et al., Jour. Med. Chem., vol. 30, pp. 91-96 (1987).

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