Naturally occurring gangliosides containing de-N-acetyl-sialic a

Details Naturally occurring gangliosides containing de-N-acetyl-sialic a Naturally occurring gangliosides containing de-N-acetyl-sialic a

1990-01-19

1993-12-21

Husarik, Nancy S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 25, 514 54, 514 62, A61K 3170, A61K 31725, C07H 506, C07H 1306

Patent

active

052721388

ABSTRACT:
A method for preparing de-N-acylated forms of an N-acyl sugar-containing glycosphingolipid and lyso forms of glycosphingolipid comprising hydrolyzing the glycosphingolipids under mild alkaline conditions such that the N-acyl group of the sugar moiety is preferentially hydrolyzed. Substantially pure gangliosides containing de-N-acetyl-sialic acid isolated from natural sources. A culture medium for stimulating growth of human and animal cells comprising: essential nutrients for cell growth, and a cell growth stimulatory amount of one or more gangliosides containing de-N-acetyl-sialic acid. A method for stimulating growth of human and animal cells cultured in vitro with a cell growth stimulatory amount of one or more gangliosides containing de-N-acetyl-sialic acid. A medicament and method for stimulating or inhibiting growth of human and animal cells by stimulating or inhibiting the production of growth stimulators selected from the group consisting of gangliosides containing de-N-acetyl-sialic acid, substances that promote synthesis of gangliosides containing de-N-acetyl-sialic acid and pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4918170 (1990-04-01), Hasegawa et al.
patent: 4968786 (1990-11-01), Ogawa et al.
Higashi et al; Analytical Biochemistry 120: 159-164 (1982).
Bremer et al; Journal of Biological Chemistry 259(11):6818-6825 (1984).
Bremer et al; Journal of Biological Chemistry 261(5):2434-2440 (1986).
Hanai et al; Biochemical and Biophysical Research Communications 147(1):127-134 (Aug. 31, 1987).
Meuenhofer et al; Biochemistry 24:525-532 (1985).

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