Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-05-08
1997-09-02
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3134
Patent
active
056631952
ABSTRACT:
The invention encompasses a method of inhibiting bone resorption in patients in need of such inhibition to a degree sufficient to halt or retard loss of bone mass, reduce fractures, improve bone repair and prevent or treat osteoporosis comprising: the administration of a non-toxic therapeutically effective amount of a selective cyclooxygenase-2 inhibitor such as the compounds of formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for the purposes described above.
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N. H. Bell, et al., Am. Journ. of Med., vol. 96, pp. 349-353 (Apr., 1994) "Diclofenac Sodium Inhibits Bone Resorption in Postmenopausal Women".
N. Lane, et al., Journ. of Bone and Mineral Research, vol. 6, No. 10, pp. 1029-1035 (1990) "Effect of Naproxen on Cancellous Bone in Ovariectomized Rats".
R.T. Turner, et al., Endocrinology, vol. 122, No. 3, pp. 1146-1150 (1988) "Tamoxifen Inhibits Osteoclast-Mediated Resortpion of Trabecular Bone on Ovarian Hormone-Deficient Rats".
Criares Theodore J.
Merck & Co. , Inc.
Panzer Curtis C.
Rose David L.
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