Treatment of atherosclerosis with angiotensin II receptor blocki

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514423, 514460, 514547, A61K 3141, A61K 3135, A61K 3140

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active

056631863

ABSTRACT:
A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II antagonist. This method of treatment can be used in conjunction with the treatment of hypertension. Substituted imidazoles such as ##STR1## are useful as angiotensin II receptor antagonists for this method of treatment. A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II receptor antagonist in combination with an HMG-Co A reductase inhibitor. A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II receptor antagonist in combination with an HMG-Co A reductase inhibitor and an angiotensin converting enzyme inhibitor. Also within the scope of this invention are pharmaceutical compositions for this method of use.

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patent: 5225428 (1993-07-01), Kramer et al.
Mol et al., "Effects of Synuinolin (MK-733) on Plasma Lipidsin Familial Hypercholesterolaemia," The Lancet, Oct. 25, 1986, pp. 936-939.
The Merck Manual, 1987, 15th Edition pp. 386-389.

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