Process for the recovery of cephalexin

Details Process for the recovery of cephalexin Process for the recovery of cephalexin

1997-07-31

1999-02-23

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

435 47, 435 50, 540215, 540230, C12P 3704, C07D50106

Patent

active

058745718

ABSTRACT:
The disclosed process is for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a pH higher than 7, which apart from any solid cephalexin being present is homogeneous at a pH between 7 and 8.5, is subjected to a pH modification until a pH lower than 7.8 is reached, and the solid substance is recovered. The disclosed process is particularly suited for application to a reaction mixture obtained after the enzymatic acylation reaction of 7-ADCA with a phenylglycine derivative as an acylation agent. Pure cephalexin can thus be recovered in a simple manner.

REFERENCES:
patent: 3883519 (1975-05-01), Fujii
patent: 4003896 (1977-01-01), Faarup
patent: 5470717 (1995-11-01), Clausen

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