Nucleic acids comprising a highly conserved novel 3 terminal seq

Details Nucleic acids comprising a highly conserved novel 3 terminal seq Nucleic acids comprising a highly conserved novel 3 terminal seq

1995-08-29

1999-02-23

Scheiner, Laurie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 243, 536 2433, 435 6, 4351723, C07H 2102, C07H 2104, C12Q 168, C12N 1500

Patent

active

058745653

ABSTRACT:
The invention relates to the discovery of a novel RNA sequence at the 3' terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3' sequence, its complement, and their use for nucleic-acid based diagnostics and for developing and evaluating novel anti-HCV therapies. This sequence element, which is conserved among HCV genotypes, is likely to be essential for viral replication, and required for construction of full-length HCV cDNA clones capable of yielding infections RNA, progeny virus or replication-competent HCV replicons. Such functional clones are useful tools for evaluation of therapeutic approaches and as substrates for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV.

REFERENCES:
Bukh et al (1995) Sem. Liver Dis. 15:41-63.
Boyer and Haenni (1994) J. Gen. Virol. 198: 415-426.
Bresters et al (1994) J. Med. Virol. 43:262-8.
Chazouilleres et al (1994) Gastroenterology 106:994-9.
Davis et al (1994) Hepatology 19:1337-41.
Feray et al (1994) Hepatology 20:1137-43.
Gordon et al (1994) Am. J. Gastroenterol. 89:1458-61.
Lin et al (1994) J. Virol. 68:5063-5073.
Okamoto et al (1994) J. Gen. Virol. 75:629-635.
Sakamoto et al (1994) J. Gen. Virol. 75:1761-1768.
Simmonds et al (1994) J. Gen. Virol. 75:1053-1061.
Tokita et al (1994) J. Gen. Virol. 75:931-936.
Wright et al (1994) Hepatology 20:773-9.
Chen et al (1992) Virology 188:102-113.
Cha et al (1991) J. Clin. Microbiol. 29:2528-34.
Inchauspe et al (1991) Proc. Natl. Acad. Sci. USA 88:10292-10296.
Mandl et al (1991) Biotechniques 10:486.
Okamoto et al (1991) J. Gen. Virol. 72:2697-2704.
Chambers et al (1990) Virology 177:159-174.
Sullenger et al (1990) Cell 63:601-608.
Umlauft et al., Hepatitis C Virus Detection by Single-Round PCR Specific for the Terminal 3' Noncoding Region, J. Clin. Micro., 34:2552-2558 (1996).
Choo et al. (1995) Proc. Natl. Acad. Sci. USA 88:2451-5.
Han et al. (1991) Proc. Natl. Acad. Sci. USA 88:1711-5.
Yoo et al. (1995) J. Virology 69:32-8.
Hahn et al. (1987) J. Mol. Biol. 198:33-41.
Kolykhalov et al. (1996) J. Virology 70:3363-71.
Tanaka et al. (1995) Biochem. Biophys. Res. Commun. 215:744-9.
Tanaka et al. (1996) J. virology 70:3307-12.
Reeck et al., 1987, Cell 50:667.
Lewin, 1987, Science 237:1570.
Strongin, W., 1993, "Sensitivity, Specificity, and Predictive Value of Diagnostic Tests: Definitions and Clinical Applications", in Laboratory Diagnosis of Viral Infections, Lennette, E., ed., Marcel Dekker, Inc., New York, pp. 211-219.

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