Nucleic acid ligand inhibitors to DNA polymerases

Details Nucleic acid ligand inhibitors to DNA polymerases Nucleic acid ligand inhibitors to DNA polymerases

1995-06-07

1999-02-23

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 912, 935 77, 935 78, C07H 2104, C07H 2102, C12Q 168, C12P 1934

Patent

active

058745572

ABSTRACT:
High-affinity oligonucleotide ligands to the thermostable Taq polymerase and Tth polymerase are disclosed. Specifically disclosed are DNA ligands having the ability to bind to the Taq and Tth polymerases and the methods for obtaining such ligands. The ligands are capable of inhibiting polymerases at ambient temperatures.

REFERENCES:
patent: 5270163 (1993-12-01), Gold et al.
patent: 5338671 (1994-08-01), Salice et al.
patent: 5459015 (1995-10-01), Janjic et al.
patent: 5472841 (1995-12-01), Jayasena et al.
patent: 5476766 (1995-12-01), Gold et al.
patent: 5496938 (1996-03-01), Gold et al.
patent: 5503978 (1996-04-01), Schneider et al.
patent: 5527894 (1996-06-01), Gold et al.
patent: 5543293 (1996-08-01), Gold et al.
patent: 5567588 (1996-10-01), Gold et al.
patent: 5580737 (1996-12-01), Polisky et al.
patent: 5587468 (1996-12-01), Allen et al.
patent: 5595877 (1997-01-01), Gold et al.
Joyce (1989) Gene 82:83.
Joyce and Inoue (1989) Nucleic Acids Research 17:711.
Ellington and Szostak (1990) Abstract of papers presented at the 1990 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 226.
Kinzler and Vogelstein (1989) Nucleic Acids Research 17:3645.
Kramer et al. (1974) J. Mol. Biol. 89:719.
Levisohn and Spiegelman (1969) Proc. Natl. Acad. Sci. USA 63:805.
Levisohn and Spiegelman (1968) Proc. Natl. Acad. Sci. USA 60:866.
Oliphant et al. (1989) Mol. Cell. Biol. 9:2944.
Oliphant and Struhl (1988) Nucleic Acids Research 16:7673.
Oliphant and Struhl (1987) Methods in Enzymology 155:568.
Oliphant et al. (1986) Gene 44:177.
Robertson and Joyce (1990) Nature 344:467.
Thiesen and Bach (1990) Nucleic Acids Research 18:3203.
Bloch (1992) Amplications, a Forum for PCR Users, Issue 8, pp. 6-9.
(1992) Amplications, A Forum for PCR Users, Issue 8, pp. 16-17.
Myers and Gelfand (1991) Biochemistry 30:7661.
Kellogg et al. (1994) BioTechniques 16:1134.
Tuerk et al. (1992) Proc. Natl. Acad. Sci. USA 89:6988-92.
Chen and Gold (1994) Biochemistry 33:8746-56.
Fujihashi et al. (1995) AIDS Research and Human Retroviruses 11:461-71.
Tokes and Aradi (1995) Biochimica et Biophysica Acta 1261:115-120.
Hacia et al. (1994) Biochemistry 33:6192-6200.
Boiziau et al. (1995) Nucl. Acids. Res. 23:64-71.
Matsukura et al. (1995) Toxicology Letters 82/83:435-38.
Takase-Yoden et al. (1995) Antiviral Res. 28:359-68.

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