Human thymosin .beta. 15 gene, protein and uses thereof

Details Human thymosin .beta. 15 gene, protein and uses thereof Human thymosin .beta. 15 gene, protein and uses thereof

1996-06-17

1997-09-02

Elliott, George C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

536 231, 536 235, 4353201, 435358, 435365, 435367, C07H 2102, C07H 2104, C12N 500, C12N 1500

Patent

active

056630719

ABSTRACT:
The present inventors have now discovered that humans have a gene that encodes a novel protein of the thymosin .beta. family. This novel protein, herein referred to as thymosin .beta.15, has the ability to bind and sequester G-actin, like other members of the thymosin .beta. family, but unlike what is known about other members it also directly regulates cell motility in prostatic carcinoma cells. The present invention is directed to an isolated cDNA encoding the human thymosin .beta.15 gene (SEQ ID NO: 1) and have deduced the amino acid sequence (SEQ ID NO: 2).

REFERENCES:
Montell et al., The drosophila ninaC locus encodes two photoreceptor cell specific proteins with domains homologous to protein kinases and the myosin heavy chain head, Cell, vol. 52, pp. 757-772 Mar. 1988.
Rudin et al., Differential splicing of thymosin .beta.-4 mRNA, J. Immunol., vol. 144(12), pp. 4857-4862 Jun. 1990.
Hiller et al., The WashU-Merck EST project, EST-STS, accession #R08518 Apr. 1995.
Nachmiar, V., Current Opinion in Cell Biology, 1993, 5:56.
Safer, et al., Proc. Natl. Acad. USA 1990 87:2536-2540.
Safter, et al., J. Biol. Chem., 1991, 268:4029-4032).
D. Safer, J. Muscle Res. Cell Motil, 1992, 13:269-271).
Weber, et al., Biochemistry 1992, 31:6179-6185).
Yu, et al., J. Biol. Chem., 1993, 268:502-509.
Cassimeris, et al., J. Cell Biol., 1992, 119:1261-1270.
Low, et al., Arch. Biochem. Biophys., 1992, 293:32-39.
Low, et al., Proc. Natl. Acad. Sci., USA 1981, 78:1162-1166.
Rebar, et al., Science 1981, 214:669-671.
Gomez-Marquez, et al., J. Immunol. 1989, 143:2740-2744.
Bao, et al., The American Association for Cancer Research annual meeting (Mar.18-22, 1995), Abstract.
Clauss, et al., Genomies 1991, 9:75-180.
Sanders, et al., Proc. Natl. Acad. Sci. USA 1992, 89:4678-4682.

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