Recombinant production of a soluble splice variant of the Fas (A

Details Recombinant production of a soluble splice variant of the Fas (A Recombinant production of a soluble splice variant of the Fas (A

1993-11-15

1997-09-02

Fitzgerald, David L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

536 235, 4353201, 4352523, 43525411, 435 691, 435348, 435361, 435358, C12N 1512, C07K 14715

Patent

active

056630700

ABSTRACT:
The invention provides soluble forms of the Fas (Apo-1 ) protein comprising both the intracellular and extracellular domains of the full-length polypeptide. Exemplified is a naturally-occurring splice variant of the Fas gene, Fas.DELTA.TM, which lacks the transmembrane domain of the native antigen. DNA encoding the protein, cells expressing the recombinant DNA, and methods of using the protein and DNA are also provided.

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