Propanolamine derivatives, processes for their preparation, phar

Details Propanolamine derivatives, processes for their preparation, phar Propanolamine derivatives, processes for their preparation, phar

1998-04-02

1999-02-23

Northington Davis, Zinna

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514256, 514314, 514332, 514340, 514357, 540596, 544333, 546176, 546255, 5462627, 5462714, 546334, C07D21302, C07D40102, A61K 3144

Patent

active

058744517

ABSTRACT:
The invention relates to substituted propanolamine derivatives and their acid addition salts.
Propanolamine derivatives of formula I, ##STR1## in which R.sup.1 to R.sup.8 have the meanings indicated in the specification, and their physiologically tolerable salts and processes for their preparation are described. The compounds are suitable, for example, as hypolipidemics.

REFERENCES:
International Search Report dated Jul. 10, 1998.
English-language Abstract of EPO 0 345 591 A1 (Derwent Abstract No. 89-365308/198950).
Lyapova, M. et al., "Diastereomers with three neighboring phenyl groups. Part IX. Optical resolution and absolute configurations of 3-amino-1,2,3-triphenylpropanols," Chem. Abs. 99(11) (Sep. 12, 1983), Abstract No. 87735.
Huang, Y. and Hall, I. H., "Hypolipidemic effects of .alpha., .beta., and .gamma.-alkylaminophenone analogs in rodents," Eur. J. Med. Chem.31:281-290 (1966).
Deutsches Arzneibuch (German Pharmacopeia), 9th ed., 1986, Deutscher Apotheker-Verlag Stuttgart, S. 19. (Table translation provided).
Pirkle, W.H. et al., "Dynamic NMR Studies of Diastereomeric Carbamates: Implications towards the Determination of Relative Configuration by NMR," J. Org. Chem., vol. 44, No. 26, pp. 4891-4896 (1979).

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