Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-12-31
1999-02-23
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514423, 514424, 546192, 546245, 548530, 548542, A61K 3140, A61K 31445, C07D20748, C07D21196
Patent
active
058744495
ABSTRACT:
This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
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patent: 5536723 (1996-07-01), Loscalzo et al.
patent: 5585397 (1996-12-01), Tung et al.
Holt, Dennis A. et al., "Structure-Activity Studies of Synthetic FKBP Ligands as Peptidyl-Prolyl Isomerase Inhibitors," Biorg. Med. Chem. Lett., 1994, 4(2) 315-320.
Holt, Dennis A. et al., "Design Synthesis, and Kinetic Evaluation of High-Affinity FKBP Ligands and the X-ray Crystal Structures of Their Complexes with FKBP12," J. Am. Chem. Soc., 1993, 115, 9925-9938.
Hamilton Gregory S.
Huang Wei
Li Jia-He
GPI Nil Holdings Inc.
Juneau Todd L.
Nath Gary M.
Oswecki Jane C.
Richter Johann
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