Synthesis of combinatorial libraries

Details Synthesis of combinatorial libraries Synthesis of combinatorial libraries

1994-06-22

1997-09-02

Green, Lora M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 436501, 436518, 436531, 436533, 530333, 530334, 536 185, 536 253, G01N 3353

Patent

active

056630468

ABSTRACT:
Directly dividing the contents of each sub-pool into the sub-pools for the next step in the synthetic scheme for producing a combinatorial library reduces the standard deviation, .sigma., relative to the standard deviation of the split synthesis method for producing such libraries.

REFERENCES:
Ohlmeyer et al. PNAS, vol. 90 pp. 10922-10926 (1993) "Complex synthetic chemical libraries indexed with molecular tags".
Needels et al. PNAS, vol. 90, pp. 10700-10704 (1993) "Generation and screening of an oligonucleotide-encoded synthetic peptide library".
DeWitt et al. PNAS, vol. 90, pp. 6909-6913 (1993) "`Diversomers`; An approach to nonpeptide, nonoligomeric chemical diversity".
R.M. Baum,C&EN, 20-25, Feb. 7, 1994.
Furka et al., "Cornucopia of Peptides by Synthesis", Abstr. 14th Int. Cong. of Biochem., Prague Czechoslovakia, vol. 5, p. 47 (1988).
Furka et al., "More Peptides by Less Labour", Abstr. 10th Int. Sym. on Med. Chem., Budapest, Hungary p. 288 (1988).
Gallop et al. Jour. Med. Chem., vol. 37, No. 9, 1233-1251, (1994).
Bernardo and Smith, Bayesian Theory, pp. 115 & 428, John Wiley & Sons (1994).
Lothar Sachs, Applied Statistics, 171-174, Springer-Verlag (1984).

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