Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-11-01
1999-02-23
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544256, C07D48704, A61K 31445
Patent
active
058744371
ABSTRACT:
Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NO.sub.n -PDE inhibitor wherein n is 1 or 2. The phosphodiesterase inhibitor can be nitrosylated or nitrosated through sites such as oxygen (hydroxyl condensation), sulfur (sulfhydryl condensation), carbon and nitrogen. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a composition comprising a therapeutically effective amount of an phosphodiesterase inhibitor (PDE inhibitor), which can optionally be substituted with at least one NO or NO.sub.2 moiety, and one to ten fold molar excess of a compound that donates, transfers or releases nitrogen monoxide as a charged species, i.e., nitrosonium (NO.sup.+) or nitroxyl (NO.sup.-), or as the neutral species, nitric oxide (NO.cndot.) or which stimulates endo genous EDRF production The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a method for treating male impotence in humans by administering the compounds and compositions thereof.
REFERENCES:
patent: 4308278 (1981-12-01), Schneider et al.
patent: 5196426 (1993-03-01), Saccomano et al.
patent: 5223504 (1993-06-01), Noverola et al.
patent: 5254575 (1993-10-01), Pick et al.
patent: 5340827 (1994-08-01), Beeley et al.
patent: 5426107 (1995-06-01), Bell et al.
patent: 5491147 (1996-02-01), Boyd et al.
patent: 5545647 (1996-08-01), Tanaka et al.
de Tejada Inigo Saenz
Garvey David S.
NitroMed Inc.
Olstein Elliot M.
Rao Deepak R.
Semionow Raina
Shah Mukund J.
LandOfFree
Nitrosated and nitrosylated phosphodiesterase inhibitor compound does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nitrosated and nitrosylated phosphodiesterase inhibitor compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitrosated and nitrosylated phosphodiesterase inhibitor compound will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-307278