Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2001-08-08
2003-09-30
Jaworski, Francis J. (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S456000, C600S453000, C600S454000, C600S468000, C073S861180
Reexamination Certificate
active
06626838
ABSTRACT:
FIELD OF THE INVENTION
This invention relates to estimation of fluid flow, and more particularly to a chronic or acute measurement of blood flow in a blood vessel.
BACKGROUND
There are many applications in clinical and research medicine in which measurement or estimation of volumetric blood flow within a blood vessel is desirable. One method of making such measurements uses ultrasonic Doppler techniques to measure blood flow velocity and thereby estimate volumetric blood flow. Velocity of an object is often measured using the Doppler effect Single frequency ultrasonic energy is transmitted into an area of tissue containing the blood flow to be measured. This insonification of the area is typically referred to as illumination Resulting ultrasonic energy is reflected, or backscattered, from the illuminated area. Energy reflected from moving targets, such as fluid and blood cells, will be shifted in frequency from the illuminating frequency according to the well-known Doppler effect The Doppler shifted frequency provides a measure of the blood flow velocity.
In clinical and research applications, it is often necessary to study blood flow for an extended period of time. Thus, in ambulatory living organisms, such as animal or human subjects, there is a need in the art to provide a battery-powered ultrasonic Doppler blood flow meter for measuring blood flow velocity for an extended period of time, allowing a human or animal patient freedom of movement during the study and minimizing the need for supervision by the clinician. There is also a need in the art to provide a small, low-power ultrasonic Doppler blood flow meter that is suitable for implantation in a human or animal subject. There is a further need in the art to provide an implantable ultrasonic Doppler blood flow meter that maintains adequate signal-to-noise (SNR) ratio for accurate velocity estimation.
SUMMARY
The present invention includes a method and apparatus for estimating blood flow or blood flow velocity in a blood vessel over a period of time. According to the method, at least part of the measurement circuits used to estimate blood flow are automatically activated only during the time an estimate is being obtained. At least part of the measurement circuits are automatically deactivated during the time an estimate is not being obtained These steps are performed repeatedly to provide a sequence of blood flow estimates forming a blood flow waveform indicative of blood flow. More than one estimate is typically required to obtain a waveform representative of the blood flow.
The steps of activating and deactivating at least part of the measurement circuits is repeatedly performed sufficiently frequently, either periodically or at irregular intervals, such that the blood flow waveform substantially represents the variable blood flow. Power to at least a portion of the measurement circuits is reduced or interrupted while the measurement circuits are deactivated.
Measurement of blood flow can be obtained through various blood flow measurement techniques, including: continuous wave (CW) Doppler flow measurement, pulsed Doppler flow measurement, laser Doppler flow measurement, transit time flow measurement, thermal dilution flow measurement, electromagnetic flow measurement, or other suitable flow measurement technique.
In several embodiments, a basebanded Doppler-shifted signal provides the blood flow estimate. In other embodiments, a blood flow output signal is derived from the basebanded Doppler-shifted signal and provided as the blood flow estimate.
Thus, the present invention provides a strobed blood flow meter, such as an implantable strobed ultrasonic Doppler blood flow meter, having reduced average power consumption, which is advantageous for reducing battery size, extending battery life, and improving signal-to-noise ratio.
REFERENCES:
patent: 4198987 (1980-04-01), Cain et al.
patent: 4227407 (1980-10-01), Drost
patent: 4622978 (1986-11-01), Matuso et al.
patent: 4787395 (1988-11-01), Yanashima et al.
patent: 4809703 (1989-03-01), Ishikawa et al.
patent: 4819860 (1989-04-01), Hargrove et al.
patent: 4866613 (1989-09-01), Amemiya et al.
patent: 4905206 (1990-02-01), Nishiyama et al.
patent: 5046500 (1991-09-01), Fehr
patent: 5083567 (1992-01-01), Uchibori
patent: 5103825 (1992-04-01), Hokanson et al.
patent: 5107466 (1992-04-01), Nishiyama et al.
patent: 5111825 (1992-05-01), Nishiyama et al.
patent: 5113867 (1992-05-01), Janszen
patent: 5156152 (1992-10-01), Yamazaki et al.
patent: 5174299 (1992-12-01), Nelson
patent: 5228449 (1993-07-01), Christ et al.
patent: 5291892 (1994-03-01), O'Donnell
patent: 5313947 (1994-05-01), Micco
patent: 5316001 (1994-05-01), Ferek-Petric et al.
patent: 5373848 (1994-12-01), Melton, Jr. et al.
patent: 5383462 (1995-01-01), Hall
patent: 5476097 (1995-12-01), Robinson
patent: 5535747 (1996-07-01), Katakura
patent: 5544656 (1996-08-01), Pitsillides et al.
patent: 5640960 (1997-06-01), Jones et al.
patent: 5865749 (1999-02-01), Doten et al.
patent: 0503839 (1992-09-01), None
patent: 1215659 (1986-02-01), None
patent: 1734697 (1992-05-01), None
“A Signal Processing Approach”,Estimation of Blood Velocities Using Ultrasound, Cambridge University Press, Great Britian, 4 Pages, (1996).
David, J., et al., “Modern Spectral Analysis Techniques for Blood Flow Velocity and Spectral Measurements with Pulsed Doppler Ultrasound”,IEEE, vol. 38, No. 6, pp. 589-596, (Jun. 1991).
Kasai, C., et al., “Real-Time Two-Dimensional Blood Flow Imaging Using an Autocorrelation Technique”,IEEE, vol. SU-32, No. 3, pp. 458-464, (May 1985).
Pitsillides, K.F., et al., “Biotelemetry of Cardiovascular Hemodynamic Measurements in Miniswine”,IEEE, vol. 39, No. 9, pp. 982-986, (Sep. 1992).
Shults, M.C., et al., “A Telemetry-Instrumentation System for Monitoring Multiple Subcutaneously Implanted Glucose Sensors”,IEEE, vol. 41, No. 10, pp. 937-942, (Oct. 1994).
Yonezawa, Y., et al., “A Miniaturized Ultrasonic Flowmeter and Telemetry Transmitter For Chronic Animal Blood Flow Measurements”,Eng. Symp. ISA Biomed. Sci. Instrument, pp. 107-111, (1989).
Yonezawa, Y., et al., “Radio Telemetry Directional Ultrasonic Blood Flowmeter for Use with Unrestrained Animals”,Med.&Biol. Eng.&Comput., pp. 659-665, (Nov. 1992).
Brockway Brian P.
Doten Gregory P.
Jaworski Francis J.
Jung William C.
Schwegman Lundberg Woessner & Kluth P.A.
Transoma Medical, Inc.
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