Human NADH dehydrogenase subunits and DNA thereof

Details Human NADH dehydrogenase subunits and DNA thereof Human NADH dehydrogenase subunits and DNA thereof

1997-04-22

1999-02-23

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 4352523, 43525233, 4353201, 435325, 536 231, 536 235, 530325, C12N 1570, C12N 1585, C12N 1512, A61K 3800

Patent

active

058742441

ABSTRACT:
The present invention provides a human NADH-D protein subunit (NDS) and polynucleotides which encode NDS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of NDS.

REFERENCES:
Cleeter, M.W.J., et al., "The polypeptide composition of the mitochondrial NADH: ubiquinone reductase complex from several mammalian species," Biochem. J., 230:739-746 (1985).
Walker, J.E., et al., "Sequences of 20 Subunits of NADH: Ubiquinone Oxidoreductase from Bovine Heart Mitochondria," J. Mol. Biol., 226:1051-1072 (1992) (GI 250; GI 254).
Ali, S., et al., "Chromosomal Localization of the Human Gene Encoding the 51-kDA Subunit of Mitochondrial Complex I (NDUFV1) to 11q13," Genomics, 18:435-439 (1993).
The Wash U-Merck EST Project, Acc # AA009413, 1995.
The Wash U-Merck ES Project, Acc # 24219, 1995.
The Wash U-Merck EST Project, Acc # AA AA203643, 1995.
The Wash U-Merck EST Project, Acc # W93566, 1995.
The Wash U-Merck EST Project, Acc # AA 024922, 1995.
The Wash U-Merck EST Project, Acc # AA11999, 1995.
The Wash U-Merck EST Project Acc # N47307, 1995.
The Wash U-Merck EST Project Acc # W72958, 1995.

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