Methods of determining the risk of pouchitis development

Surgery – Miscellaneous – Methods

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435 4, A61B 1900

Patent

active

059378620

ABSTRACT:
Provided is a method of determining a risk of pouchitis development following a surgical procedure whereby colon is removed and an internal pouch is created in a patient with UC by determining a first pANCA titer, where the first pANCA titer is determined following the surgical procedure; determining a second pANCA titer at a later time; and comparing the first pANCA titer and the second pANCA titer, where a significantly elevated second pANCA titer indicates an increased risk of pouchitis development. Also provided is a method of determining a risk of pouchitis development following a surgical procedure whereby colon is removed and an internal pouch is created in a patient with UC by determining a first pANCA titer, where the first pANCA titer is determined prior to the surgical procedure; determining a second pANCA titer following said surgical procedure; and comparing the first pANCA titer and the second pANCA titer, where a significantly elevated second pANCA titer indicates an increased risk of pouchitis development.

REFERENCES:
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Madden et al., "Inflammation in Ileal Reservoirs: `Pouchitis,`" Gut 31:247-249 (1990).
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Sandborn et al., "The Presence of Antineutrophil Cytoplasmic Antibody Correlates with Pouchitis After Ileal Pouch-anal Anastomosis for Ulcerative Colitis," Gastroenterol. 104: A774 (1993).
Saxon et al., "A Distinct Subset of Antineutrophil Cytoplasmic Antibodies is Associated with Inflammatory Bowel Disease," J. Allergy Clin. Immunol. 86:202-210 (1990).
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Vecchi et al., "P-ANCA and Development of Pouchitis in Ulcerative Colitis Patients After Proctocolectomy and Ileoanal Pouch Anastomosis," The Lancet 344:886-887 (1994).

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