Method and apparatus for treatment of focal disease in hollow tu

Details Method and apparatus for treatment of focal disease in hollow tu Method and apparatus for treatment of focal disease in hollow tu

1994-04-13

1997-09-02

Buiz, Michael

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

606194, A61M 2500, A61M 2900

Patent

active

056626096

ABSTRACT:
The present invention provides a technique for treating diseased portions of tissue lumens by the focal introduction of at least one therapeutic agent at the diseased region. A catheter is positioned in a lumen such that first and second expansile members surround the diseased portion of tissue. The expansile members are expanded to occlude the diseased region and a therapeutic agent is introduced to the occluded diseased region via the catheter. The catheter is allowed to remain in place for a therapeutically effective period of time to allow the therapeutic agent to contact the diseased portion for such a period of time. The catheter arrangement also can be used to occlude a diseased region, remove physiological fluid from the occluded region and subsequently to disrupt the diseased region and/or apply the therapeutic agent. The therapeutic agent can be selected to suppress cell proliferation in the diseased region, and the occluded region can be treated with a medicament to promote vessel healing. The occluded region also can be paved with polymeric material. Finally, the expansile members are contracted and the catheter is removed.

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