dapE gene on Helicobacter pylori and dapE− mutant...

Details dapE gene on Helicobacter pylori and dapE− mutant... dapE gene on Helicobacter pylori and dapE− mutant...

1999-12-09

2003-05-27

Smith, Lynette R. F. (Department: 1645)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C514S04400A, C435S069100, C435S252300

Reexamination Certificate

active

06570004

ABSTRACT:

BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention pertains to the dapE gene of
Helicobacter pylori
and
H. pylori
dapE
−
mutants and to methods of using the mutants to express foreign genes and immunize against foreign agents.
2. Background Art
Helicobacter pylori
are gram negative enteric bacteria that colonize the human gastric mucosa and cause gastritis and peptic ulcer disease (6,11,15) and are implicated in malignant neoplasms of the stomach (5,26,30,37). Thus, there exists a need for a method of treating and preventing
H. pylori
infection.
The present invention meets these needs by providing the dapE gene of
H. pylori
and conditionally lethal mutants of
H. pylori
which can be used to express foreign proteins and to immunize against
H. pylori
infection.


REFERENCES:
patent: 5919462 (1999-07-01), Narwa et al.
patent: 95/14772 (1995-06-01), None
patent: 96/40893 (1996-12-01), None
Karita, M. et al., Characterization ofHelicobacter pyloridapE and construction of a conditionally lethal dapE mutant,Infection and Immunity, 1997, vol. 65, No. 10 pp. 4158-4164.

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