Liquid purification or separation – Processes – Chromatography
Patent
1997-08-15
1998-10-13
Therkorn, Ernest G.
Liquid purification or separation
Processes
Chromatography
2101982, B01D 1508
Patent
active
RE0359190
DESCRIPTION:
BRIEF SUMMARY
INDUSTRIAL APPLICABILITY
The present invention relates to a novel process for separating optical isomers.
BACKGROUND ART
As well known in the art, optical isomers generally have different activities to living bodies, even though they are chemically the same compounds. Accordingly, in the fields of pharmaceuticals, pharmaceutical manufacture and biochemistry-related industries, it is an extremely important task to prepare optically pure compounds in order to improve the efficacy of pharmaceuticals per unit dose and to avoid the side effects and damages caused by pharmaceuticals. The separation of an optical isomer mixture, that is, optical resolution, has been performed according to the diastereomer method, the crystallization method, the enzyme method and the separating membrane method. In these methods, however, the types of compounds for which optical resolution is feasible are often limited, so that they are not suitable for general purposes. Although chromatography is available for such separation, currently known chromatographic methods are of batch type, so that noncontinuous and nonsteady operations are inevitable and hence they are not suitable for the separation in a large quantity. In addition, a large quantity of an eluent is needed to and the concentration of the desired compound in an eluate is extremely low, so that there has been a drawback that much energy and complicated process are required for recovery. Therefore, the development of a method capable of efficient separation in a large quantity has been desired in the art.
DISCLOSURE OF THE INVENTION
The present invention provides a novel process capable of efficiently separating an optical isomer. The present inventors have made extensive studies to find out that efficient separation of an optical isomer in a large quantity can be performed by the use of a simulated moving bed system, which has led to the completion of the present invention.
Accordingly, the present invention relates to a process for separating optical isomers in a simulated moving bed system, characterized by introducing a solution containing an optical isomer mixture and a desorbing liquid into a packed bed containing an optical resolution packing therein and having front and rear ends thereof connected to each other endlessly via a fluid passage to circulate a fluid unidirectionally and at the same time drawing out a solution containing one of the separated isomers and another solution containing the other isomer from the packed bed, wherein a port for introducing a desorbing liquid, a port for drawing out a solution containing a strongly adsorbable optical isomer, i.e. an extract, a port for introducing a solution containing an optical isomer mixture, and a port for drawing out a solution containing a weakly adsorbable optical isomer, i.e. a raffinate, are arranged in the packed bed in this order along the direction of fluid flow and the positions of these ports are successively moved in the direction of fluid flow in the packed bed intermittently.
The simulated moving bed system means a system in which ports for introducing a desorbing liquid and ports for drawing out an adsorbate fluid are arranged in a packed bed containing a solid adsorbent therein and having front and rear ends thereof connected to each other via a fluid passage to circulate a fluid, along the direction of fluid flow in the bed, an upstream introduction port and an upstream draw-out port being successively changed over by the downstream counterparts at given time intervals, respectively, to thereby separate a feedstock fluid into a component (adsorbate component) which is relatively strongly adsorbed by the solid adsorbent and a component (nonadsorbate component) which is relatively weakly adsorbed by the solid adsorbent. The simulated moving bed system per se is known in the art (see for example, Japanese Patent Publication No. 15681/1967). This simulated moving bed technology has been utilized in, for example, the manufacture of fructose, the separation of maltose and the recovery of coe
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Shoji Fumihiko
Yamashita Akira
Daicel Chemical Industries Ltd.
Therkorn Ernest G.
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