Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-10-07
1985-11-05
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548494, A61K 31405, C07D20920
Patent
active
045514712
ABSTRACT:
The process for the biosynthesis of 3-indolpyruvic acid involves the reaction of tryptophan with purified enzyme aspartate aminotransferase obtained from the mytochondria of slaughterhouse animals. When administered orally in rats, 3-indolpyruvic acid leads to a considerable increase in cerebral serotonin levels, and so may be used in all the pathological conditions of the central nervous system involving deficiencies of this neurotransmitter, such as depressions, insomnia, lack of appetite, neuroendocrin imbalances, etc.
REFERENCES:
Richards, J. Nutrition, vol. 102, pp. 1547-1550 (1972).
Haavaldsen, Biochemical Journal, 92, p. 23 (1964).
Truzhnikova et al., C.A., 75, 138075h (1971).
Grigor'ev et al., C.A., 75, 46021j (1971).
Akabori et al., C.A. 13146c (1960).
De Luca Giovanna
Di Stazio Giovanni
Materazzi Mario
Politi Vincenzo
Polifarma S.p.A.
Raymond Richard L.
Springer D. B.
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