1,2-Dihydro-5-pyridinyl-3H-pyrazolo[3,4-b]pyridin-3-ones and the

Details 1,2-Dihydro-5-pyridinyl-3H-pyrazolo[3,4-b]pyridin-3-ones and the 1,2-Dihydro-5-pyridinyl-3H-pyrazolo[3,4-b]pyridin-3-ones and the

1980-03-17

1981-05-05

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546119, 546257, 546258, C07D47102, A61K 31415

Patent

active

042658950

ABSTRACT:
1,2-Dihydro-1-R-5-PY-6-Q-3H-pyrazolo[3,4-b]pyridin-3-ones or pharmaceutically-acceptable acid-addition salts thereof, which are useful as cardiotonic agents, are prepared by reacting lower-alkyl 2-halo-5-PY-6-Q-nicotinate with 1-R-hydrazine. Also disclosed are cardiotonic compositions and method for increasing cardiotonic contractility using said compounds or salts.

REFERENCES:
patent: 3423414 (1969-01-01), Blatter
patent: 4004012 (1977-01-01), Lesher et al.
patent: 4072746 (1978-02-01), Lesher et al.
patent: 4107315 (1978-08-01), Lesher et al.
C.A., 87, (1977), 39357t, Balicki, et al.
Balicki et al., Acta Poloniae Pharmaceutica, (1976), vol 33 (3), pp. 289-293.
Nantka-Namirski, et al., Pol. J. Pharmacol. Pharm., (1978), vol. 30, pp. 707-712.

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