Substituted thiazolo[3,2-a]pyrimidines and process for their pre

Details Substituted thiazolo[3,2-a]pyrimidines and process for their pre Substituted thiazolo[3,2-a]pyrimidines and process for their pre

1984-05-30

1985-11-05

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544278, 544281, 544282, C07D51304, A61K 31505

Patent

active

045514577

ABSTRACT:
Pharmacologically active thiazolo[3,2-a]pyrimidines of the formula ##STR1## wherein A is a bond between the .alpha.- and .beta.-carbon atoms or (--CH.sub.2 --) group; R.sub.1 and R.sub.2 represent hydrogen, C.sub.1 -C.sub.4 alkyl, cyano, CF.sub.3, thienyl, pyridyl, biphenyl, naphtyl, phenyl optionally substituted, ##STR2## wherein R' and R" are hydrogen or alkyl; R.sub.3 represents hydrogen, halogen, alkyl, OH, formyloxy, alkanoyloxy, alkenyloxy; R.sub.4 represents substituted pyrrole, substituted phenyl or substituted thiazolyl. The compounds have antiinflammatory, antiulcerorgenic and antigastric secretory activity.

REFERENCES:
patent: 4444773 (1984-04-01), Doria et al.

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