Purification of interferon by metal chelate chromatography

Details Purification of interferon by metal chelate chromatography Purification of interferon by metal chelate chromatography

1984-02-27

1985-11-05

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, C07G 700, A61K 4502

Patent

active

045512710

ABSTRACT:
The purification of solutions of recombinant interferons is achieved by chromatography on metal chelate resins of the formula ##STR1## in which Me represents copper or nickel.

REFERENCES:
patent: 4257938 (1981-03-01), Hosoi et al.
patent: 4278661 (1981-07-01), Knight, Jr.
patent: 4359389 (1982-11-01), Heine
patent: 4440675 (1984-04-01), Braude
Handbook and General Catalog of Pierce Chemicals, (1983).
J. Biol. Chem., 252 (1977), 5934-5935, Edy et al.
Nature, 258, (1975), 598-599, Porath et al.
T. J. Gen. Virol., 43 (1979), 701-706, Chadha et al.
J. Chromatograph, 198, (1980), 247-255, Hubert et al.

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