Soft steroids having anti-inflammatory activity

Details Soft steroids having anti-inflammatory activity Soft steroids having anti-inflammatory activity

1985-12-09

1991-02-26

Friedman, Stanley J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

552611, 552612, C07J 300, A01N 4350

Patent

active

049963350

ABSTRACT:
The invention provides novel soft steroidal anti-inflammatory agents, pharmaceutical compositions containing said agents, and methods of administering same to mammals in the treatment of inflammation. Preferred compounds of the invention include haloalkyl 17.alpha.-alkoxycarbonyloxy-11.beta.-hydroxyandrost-4-en-3-one-17.beta.-ca rboxylates and the corresponding .DELTA..sup.1,4 compounds, optionally bearing 6.alpha.- and/or 9.alpha.-fluorine and 16.alpha.- or 16.beta.-methyl substituents. Especially preferred compounds include haloalkyl 17.alpha.-alkoxycarbonyloxy-9.alpha.-fluoro-11.beta.-hydroxy-16-methylandr osta-1,4-dien-3-one-17.beta.-carboxylates.

REFERENCES:
patent: 3558675 (1971-01-01), Sarett et al.
patent: 3856828 (1974-12-01), Phillipps et al.
patent: 4093721 (1978-06-01), Phillipps et al.
patent: 4242334 (1980-12-01), Stache et al.
patent: 4263289 (1981-04-01), Edwards
patent: 4377575 (1983-03-01), Stache et al.

Affiliated with

Also associated with

Rating

Soft steroids having anti-inflammatory activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Soft steroids having anti-inflammatory activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Soft steroids having anti-inflammatory activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-294862