Dibenzo[a,d]cycloheptenylidene compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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546203, C07D21170

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active

049963210

ABSTRACT:
Various cyproheptadine derivatives sensitize multidrug resistant cells to certain chemotherapeutic agents. As such, these cyproheptadine derivatives are useful as adjuncts in the reversal of multidrug resistance in mammalian tumor cells either as compounds, pharmaceutically acceptable salts, or pharmaceutical composition ingredients in combination with anticancer chemotherapeutic agents or compounds.

REFERENCES:
patent: 3326924 (1967-06-01), Villani
patent: 4020169 (1977-04-01), Remy et al.
patent: 4031222 (1977-06-01), Remy
Ganapathi et al., Cancer Research, 43, 3696 (1983).
Randall et al., J. Med. Chem., 22, 1222 (1979).
Remy et al., J. Org. Chem., 41, 1644 (1976).
Remy et al., J. Med. Chem., 20, 1013 (1977).
Rogan et al., Science, 224, 994 (1984).
Rothenberg et al., J. Nat. Cancer Inst., 81, 907 (1989).
Tsuruo et al., Cancer Research, 41, 1967 (1981).
Tsuruo et al., Cancer Research, 42, 4730 (1982).
Tsuruo et al., Cancer Research, 43, 2905 (1983).

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