Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-08-31
1991-02-26
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549265, 549267, 549270, 549271, A61K 31365, C07D30312, C07D31308
Patent
active
049962299
ABSTRACT:
Scytophycins A, B, C, D and E, an aldehyde and alcohol derivative of scytophycin B and the specified alkanoyl and benzoyl esters of scytophycins A, B, C, D and E and the B derivatives (scytophycin compounds) are novel antineoplastic and antifungal agents. Antifungal compositions containing a scytophycin compound and methods of inhibiting fungi, especially plant pathogenic fungi, using these compositions are included. A method for producing the scytophycin complex, comprising scytophycins A, B, C, D and E, using a new strain of the blue-green alga Scytonema pseudohofmanni, and a biologically purified culture of the alga are also provided.
REFERENCES:
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S. Carmely et al., "Structure of Swinholide-A, A New Macrolide from the Marine Sponge Theonella Swinhoei", Tetrahedron Letters, 1985, 511-514.
R. E. Moore, "Toxins from Blue-Green Algae", Bioscience 27 (12), 797-802.
R. E. Moore et al., "Toxins from Cyanophytes Belonging to the Scytonemataceae," Pure & Appl. Chem. 58 (2), 263-271 (1986).
J. A. Roesener et al., "Ulapualide A and B, Extraordinary Antitumor Macrolide from Nudibranch Eggmasses," J. Am. Chem. Soc., 1986, 108, 846-847.
S. Matsunaga et al., "Kabiramide C, a Novel Antifungal Macrolide from Nudibranch Eggmasses," J. Am. Chem. Soc., 1986, 108, 847-849.
Chemical Abstracts (1987), 106:153049e, Moore et al., "Scytophycins, Potent Cytotoxic Macrolides from Blue-Green Alga."
M. Ishibashi et al., J. Org. Chem. (1986), 51, 5300-5306, "Scytophycins, Cytotoxic and Antimicotic Agents from the Cyanophyte Scytonema pseudohofmanni."
Furusawa Eiichi
Moore Richard E.
Mynderse Jon S.
Norton Ted R.
Patterson Gregory M. L.
Eli Lilly and Company
Harrison Nancy J.
Raymond Richard L.
Russell Mark W.
University of Hawai'i
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