Process for carbapenem intermediates

Details Process for carbapenem intermediates Process for carbapenem intermediates

Filed on

1989-03-03

Date issued

1990-10-02

Examiner

Gerstl, Robert

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Heterocyclic carbon compounds containing a hetero ring...

Other Related Categories

540302, C07D20508

Type

Patent

Status

active

Patent number

049608797

Description

ABSTRACT:
A novel intermediate for synthesizing 1 .beta.-alkyl-1-carbapenem, i.e., 4 .beta.-(1 .beta.-alkyl-2-carboxyprop-2-enyl)azetidin-2-one (II), is prepared stereoselectively by treating 4-(leaving group substituted)azetidin-2-one (I) with trans-2-(leaving group substituted)-methyl-3-alkylacrylic acid (III) and a reducing metal. ##STR1## wherein R.sup.1 is hydrogen, alkyl, or substituted alkyl;

REFERENCES:
March, Advanced Organic Chemistry, pp. 405-407.

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