Cyanomethylthioacetylcephalosporins

Details Cyanomethylthioacetylcephalosporins Cyanomethylthioacetylcephalosporins

1974-10-10

1976-03-16

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50120

Patent

active

039445461

ABSTRACT:
New cyanomethylthioacetylcephalosporins of the following general formula, and their salts ##EQU1## wherein R is hydrogen or a salt forming ion of the group consisting of aluminum, alkali metal, alkaline earth metal, lower alkylamine, phenyl-lower alkylamine, N,N-dibenzylethylenediamine, procaine or lower alkylpiperidine; R.sub.1 and R.sub.2 each is hydrogen, lower alkyl, lower alkenyl, phenyl, hydroxyphenyl, chlorophenyl, benzyl, phenethyl, or R.sub.1 and R.sub.2 together complete a cyclopentyl or cyclohexyl group; R.sub.3 is phenyl, substituted phenyl or thienyl, said phenyl substituents being halogen, lower alkyl, amino or lower alkoxy; and X is hydrogen, lower alkoxy, lower alkylthio or lower alkanoyloxy; are useful as antibacterial agents.

REFERENCES:
patent: 3855212 (1974-12-01), Breuer

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