Medrogestrone production

Details Medrogestrone production Medrogestrone production

1994-05-05

1995-06-27

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

552510, 552583, C07J 700, C07J 7100

Patent

active

054281512

ABSTRACT:
A process for the production of medrogestone, in which, in an intermediate step, the solvate 3.beta.,5.alpha.,6.beta.-trihydroxy-6.alpha.,17.alpha.-dimethylpregnan-20- one monomethanolate is obtained as a solid, stable compound by displacing the organic solvent from a solution of of 3.beta.,5.alpha.,6.beta.-trihydroxy-6.alpha.,17.alpha.-dimethylpregnan-20- one with a lower alkanol, and a Diels-Alder adduct of 6-methylene-17.alpha.-methylpregn-4-ene-3,20-dione with maleic anhydride is used as an intermediate for production of the corresponding dicarboxylic acid salt for removal of 6-methylene-17.alpha.-methylpregn-4-ene-3,20-dione contamination of the desired product. Another intermediate, 6.beta.-hydroxy-6.alpha.,17.alpha.-dimethylpregn-4-ene-3,20-dione, has been found to prevent smooth muscle proliferation and is useful in the treatment of atherosclerosis and restinosis.

REFERENCES:
patent: 2387830 (1945-10-01), Butz
Deghenghi et al., J. Med. Chem., 6, 301 (1963).
Yadav et al., Syn. Commun., 19 (5&6), 1057 (1989).
Carruthers et al., J. Org. Chem., 57, 961 (1992).
Posner et al., Tet. Letts., 32 (45), 6489 (1991).
Graber et al., J. Org. Chem., 27, 2534 (1962).
Bernstein et al., J. Org. Chem., 26, 269 (1961).

Affiliated with

Also associated with

Rating

Medrogestrone production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Medrogestrone production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Medrogestrone production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-288572