Imidazopyridines

Details Imidazopyridines Imidazopyridines

1993-12-16

1995-02-14

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544235, 544238, 544284, 544333, 544362, 546118, A61K 31435, C07D47104

Patent

active

053896424

ABSTRACT:
Novel imidazopyridine derivatives of the formula I ##STR1## in which R is ##STR2## and R.sup.1 to R.sup.4, X and Y are as defined herein, and their salts have antagonistic properties towards angiotensin(II) and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure and also disorders of the central nervous system.

REFERENCES:
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patent: 5036048 (1991-07-01), Watkins
patent: 5102880 (1992-04-01), Chakravarty et al.
patent: 5157026 (1992-10-01), Chakravarty et al.
patent: 5223499 (1993-06-01), Greenlee et al.
Chiu et al., "Nonpeptide Angiotensin II Receptor Antagonists. III. Structure-Function Studies", The Journal of Pharmacology and Experimental Therapeutics, vol. 250, No. 3 (1989), pp. 867-874.
Wong et al., "Nonpeptide Angiotensin II Receptor Antagonists. VIII. Characterization of Functional Antagonism Displayed by DuP 753, an Orally Active Antihypertensive Agent", Journal of Pharmacology and Experimental Therapeutics, vol. 252, No. 2 (1990), pp. 719-725.

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