3-aryloxmethyl-cephalosporin derivatives, and their medical use

Details 3-aryloxmethyl-cephalosporin derivatives, and their medical use 3-aryloxmethyl-cephalosporin derivatives, and their medical use

1992-05-05

1995-02-14

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540222, C07D50126, A61K 31545

Patent

active

053896262

ABSTRACT:
Compounds of formula (I): ##STR1## in which: R.sup.1 is hydrogen or acyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkoxy; and Ar is phenyl or substituted phenyl and pharmaceutically acceptable salts and esters thereof have valuable antibiotic activity, including against Methicillin-resistant strains of Staphylococcus. The invention also provides a process for preparing the compounds and methods and compositions using them.

REFERENCES:
patent: 4535156 (1985-08-01), Blumbach et al.
patent: 4912212 (1990-03-01), Ochiai et al.
patent: 4918070 (1990-04-01), Nakagawa et al.
patent: 4992431 (1991-02-01), Heyms et al.
patent: 5112967 (1992-05-01), Keith et al.
Chemical Abstracts vol. 177:7704(a) 1992.
Chemical Abstracts vol. 115:158830l(1991).
Chemical Abstracts vol. 113:152140k (1989).
Chemical Abstracts vol. 107:115432n (1987).
Hiroshi Sadaki et al, "Studies on .beta.-Lactam Antibiotics for Medicinal Purpose. XVIII. Synthesis and Structure-Activity Relationships of 7.beta.-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyimino-acetamido]-3-substitut ed Methyl-3-cephem-4-carboxlic Acid Derivatives", Yakugaku Zasshi, 106(2), 129-146, (1986), Japan.
Chemical Abstracts, 107, 612 (1987) 107:115432n.

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