Method of reducing elevated blood sugar in humans

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

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514866, A61K 31045

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054280664

ABSTRACT:
A method of treating a cluster of diseases associated with elevated blood sugar levels comprising the administration of a dietary supplement of chiro-inositol. Chiro-inositol is an essential element for the synthesis of an insulin-directed mediator apparently responsible for the activation of pyruvate dehydrogenase-phosphatase. Disease conditions commonly associated with insulin-resistance, such as hypertension, lactic acidosis, obesity, coronary artery disease, and the like, are treated by administration of sufficient chiro-inositol to meet normal metabolic levels.

REFERENCES:
patent: 4446064 (1984-05-01), Larner
patent: 4735936 (1988-04-01), Siren
patent: 4797390 (1989-01-01), Siren
patent: 4801597 (1989-01-01), Stacpoole et al.
patent: 4839466 (1989-06-01), Saltiel
patent: 4906468 (1990-03-01), Saltiel
patent: 4927831 (1990-05-01), Malamas
patent: 5019566 (1991-05-01), Siren
patent: 5023248 (1991-06-01), Siren
patent: 5091596 (1992-02-01), Kennington et al.
patent: 5122603 (1992-06-01), Larner
patent: 5124360 (1992-06-01), Larner
patent: 5183764 (1993-02-01), Kennington
patent: 5217959 (1993-06-01), Sabin
patent: 5342832 (1994-08-01), Siren
Cecil "Textbook of Medicine" Saunders Co. p. 1059 (1983).
Price, et al., Effect of Aldose Reductase and Resistance to Ischemic Diabetes, Diabetes, 37(7), pp. 969-973, (Eng) 1988.
Knudsen, et al., Myo-inositol Normalizes Decreased Sodium Permeability of the Blood-brain Barrier in Streptozotocin Diabetes, Neuroscience (Oxford), 29(3), pp. 773-777, (Eng) 1989.
Hallman, et al., Inositol Supplementation in Respiratory Distress Syndrome: Relationship Between Serum Concentration, Renal Excretion and Lung Effluent Phospholipids, Pediatrics, vol. 110, No. 4, pp. 604-610, 1987.
Clements, New Therapies for Chronic Complications of Older Diabetes Patients, American Journal of Medicine, 80 (Supp ISA), pp. 54-60, 1986.
Holub, The Nutritional Significance, Metabolism and Function of Myo-inositol and Phosphatidylinosital in Health and Disease, Advanced Nutrition Research, vol. 4, pp. 107-141, 1982.
Windholz, The Merck Index, No. 4861, p. 722, 1983.
Hamster Diet Inositol as Part of Vitamin Mix, ICN Catalogue, p. AD-19, 1989.
Phillips, et al., Cyclitols in Soybean, J. Agric. Food Chem., 30(3) pp. 456-458, 1982.
Baumgartner, et al., Isolation and Identification of Cyclitols in Carob Pods, J. Agric. Food Chem., 34(5), pp. 827-829, 1986.
Williamson, et al., Diabetes-Induced Increases in Vascular Permeability and Changes in Granulation Tissue Levels of Sorbitol, Myo-inositol, Chiroinositol, and Scyllo-inositol are Prevented by Sorbinil, Metabolism, vol. 35, No. 4, Suppl. 1, pp. 41-45, Apr. 1986.
Narayanan, et al., Pinitol-A New Anti-Diabetic Compound From the Leaves of Bougainvillea-Spectabilis, Current Science, vol. 56, No. 3, pp. 139-141, (Feb. 5, 1987).
Clements, et al., Myoinositol Metabolism in Diabetes Mellitus, Diabetes, vol. 26, No. 3, pp. 215-221, 1977.
Larner, J. Cyclic Nucleotide Res. 8, 1982, pp. 289-296.
Niwa et al., J. Chromatography, 277, 1983, pp. 25-39.
Larner et al., Rec. Progress in Hormone Res. 38, 1982, pp. 511-556.
Cheng, et al., Diabetes, 29 1980, pp. 659-661.
Thompson, et al., Mol Cell. Biochem. 62, 1984, pp. 67-75.
Cheng, et al., J. Biol. Chem., 260(9), 1985, 5279-5285.
Messina, et al., Endocrinology 121, (4) 1987, pp. 1227-1232.
Malchoff, et al., Endocrinology, 102, (4), 1987, pp. 1327-1337.
Cheng, et al., Ann. Rev. Physiol., 47, 1985, pp. 405-424.
Suzuki, et al., J. Biol. Chem., 262(7), 1987, pp. 3199-3204.
Sato, et al., Arch. Biochem. Biophys. 260, 1988, pp. 377-387.
Greene, et al., J. Clin., Invest., 72, 1983 pp. 1058-1063.
Greene, et al., J. Clin. Invest. 55, 1975, pp. 1326-1336.
Clements, et al., Diabetes, 26(3), 1977, pp. 215-221.
Saltiel, et al., Proc. Natl. Acad. Sci. USA, 83, 1986 pp. 5793-5747.
Mato, et al., Biochem. Biophys. Res. Commun. 146(2), 1987, pp. 764-779.
Larner, et al., Biochem. Biophys. Res. Commun. 151(3), pp. 1416-1426 (1988).
Mato, et al., J. Biol. Chem., 262(5), 1987, pp. 2131-2137.
Romero, et al., Science, 240, 1988 pp. 504-511.
Kennington et al., J. Cell Biochem. Suppl. 0(13 part A), 1989 p. 142.
Sato, et al., Endocrinology, 123(3), 1988, pp. 1559-1564.
Huang, et al., FASEB, 1988, Abstract 1626.
Kennington, et al., Analytical Biochem. 181, 1989, pp. 1-5.

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