Heteroarylnaphthalene lactones as inhibitors of leukotriene bios

Details Heteroarylnaphthalene lactones as inhibitors of leukotriene bios Heteroarylnaphthalene lactones as inhibitors of leukotriene bios

1992-08-27

1995-06-27

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514468, 549299, A61K 3136, A61K 31365

Patent

active

054280605

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

REFERENCES:
patent: 4486445 (1984-12-01), Patel et al.
patent: 4937373 (1990-06-01), Carson et al.
patent: 5227399 (1993-07-01), Young et al.
patent: 5252599 (1993-10-01), Girard et al.
The Merck Index, 11th ed., 5154, p. 829 (1989).

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