Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-09-28
1995-06-27
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514343, 514423, 514426, 546281, 548518, 548527, 548539, 548540, 548557, A61K 3140, C07D20750, C07D40306
Patent
active
054280532
ABSTRACT:
There are disclosed 1-aminoacetamidopyrroles and 1-amino-2-(substituted) pyrroles and related compounds of the formula ##STR1## wherein all substituents are defined herein, which are useful as glycine partial agonists and for the enhancement of learning and memory and for the treatment of memory dysfunctions associated with neurodegenerative disorders and are thus indicated in the treatment of Alzheimer's disease and other senile dementias.
REFERENCES:
patent: 4517195 (1985-05-01), Effland et al.
patent: 4588727 (1986-05-01), Effland et al.
Jones, D. W., "Reaction of Phthalimidonitrene with Furans", J.C.S. Perkin I, No. 21, 1972, pp. 2728-2731.
Jacobi, P. A. et al., "A Novel Synthesis of Pyrromethenones", Tetrahedron Letters, vol. 29 No. 38, 1988 pp. 4823-4826.
Hamer, R. et al., "Synthesis of 5-Phenylpyrrolo[1,2,6][1,2,5]-triazepin-2(3H)-ones[1]", J. Heterocyclic Chemistry, vol. 25, No. 2, 1988, pp. 517-521.
Flanagan Denise M.
Kosley, Jr. Raymond W.
Kuerzel Gert U.
Martin Lawrence L.
Nemoto Peter A.
Haley Jacqueline
Hoechst-Roussel Pharmaceuticals Inc.
Korsen Elliott
Lee Mary C.
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