Differential diagnosis and treatment of the states of growth hor

Details Differential diagnosis and treatment of the states of growth hor Differential diagnosis and treatment of the states of growth hor

1992-09-18

1995-06-27

Walsh, Stephen G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514401, 436518, 436542, 436536, A61K 31415, A61K 3825, A61K 3827, A61K 4900

Patent

active

054280133

ABSTRACT:
Differential diagnosis of diverse GH-deficient states may be effectively established by cojointly administering an alpha-2-adrenergic agonist, such as clonidine, and a growth hormone releasing peptide such as GHRH. In addition, some children with short stature and showing a positive response to this test may effectively be treated with such administration.

REFERENCES:
patent: 4747825 (1988-05-01), Linkie et al.
patent: 5065747 (1991-11-01), Bercu
patent: 5120713 (1992-06-01), Mugica
Van Vliet et al, "Growth Hormone Treatment . . . ", New Eng J. Med. 309: 1016-1022, (1983).
Reiter et al, "Modulation of GHRH-Induced . . . ", J. Ped. Endocrin. 3(1): 21-25 (1988).
Gil-Ad et al, "Oral clonidine as a growth hormone stimulation test", The Lancet 2:278-280 (1979).
Devesa et al, ".alpha..sub.2 -adrenergic agonism enhances the growth hormones . . . " J. Clin. Endo. & Metab. 71(6):1581-1588 (1990).

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