Substituted thiazolo [3,2-a]-thiopyrano[4,3-d]pyrimidines

Details Substituted thiazolo [3,2-a]-thiopyrano[4,3-d]pyrimidines Substituted thiazolo [3,2-a]-thiopyrano[4,3-d]pyrimidines

1978-03-24

1978-12-05

Curtis, Allen B.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424246, 542449, 544 34, 544252, A61K 3118, C07D40914

Patent

active

041286472

ABSTRACT:
2,3,8,9-Tetrahydro-5H,6H-thiazolo[3,2-a]thiopyrano[4,3-d]pyrimidines of the structure ##STR1## are provided wherein R is hydrogen, lower alkyl, halogen, acyl, cyano, carboxyl, trifluoromethyl or lower alkoxy, n is 0 or 2 and m is 2 or 3. These compounds are useful in the treatment of auto-immune disorders, such as rheumatoid arthritis.

REFERENCES:
patent: 3636041 (1972-01-01), Schmidt et al.
patent: 3657245 (1972-04-01), Bormann et al.
Khodzhibaev et al., "Reaction of CO with 4-Me-5-carbethoxy-2-Aminothiazole," in Chem. Abs. 85:21277r, 1976, vol. 85, p. 21285.

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