Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from cinnamomum
Reexamination Certificate
2001-01-10
2002-07-02
Tate, Christopher R. (Department: 1651)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from cinnamomum
C424S725000, C424S746000, C424S754000, C424S773000, C424S775000, C424S776000
Reexamination Certificate
active
06413554
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a gelenic composition effective for prevention and treatment of hyperlipidemia, and angina pectoris due to ischemia and reperfusion. More specifically, the present invention relates to a galenic composition effective for prevention and treatment of hyperlipidemia and cardiovascular disorders, particularly, angina pectoris due to myocardial ischemia, which contains eight (8) kinds of medicinal herbs consisting of
Allium thumbergii
, trichosanthis semen, angelicae gigantis radix, salviae radix, cinnamomi ramulus, curcumae tuber, paeoniae rubrae radix and pinelliae rhizoma as the major ingredients.
BACKGROUND OF THE INVENTION
In many countries, including Korea, which are under gradual Westernization of dietary life and cultural activities, diseases of adult peoples have been raised as one of serious social problems. Among them, particularly, hyperlipidemia which attacks preferentially the middle forties and has been known as a typical type of diseases developed predominantly in advanced countries has also been raised as one of most common diseases of adult peoples. Hyperlipidemia, which has been known as the main cause of arteriosclerosis and as having a deep correlation with angina pectoris, myocardial infarction and cerebral apoplexy, generally means the blood cholesterol level of 240 mg/dl or more, and it has been proposed that blood cholesterol level should be lowered to the normal value below 200 mg/dl. The major constituents of lipid present in blood are generally classified into total cholesterol, which is commonly called cholesterol, neutral fat (triglyceride), low density lipoprotein, very low density lipoprotein and high density lipoprotein. It has been disclosed that the cause of hyperlipidemia includes heredity, alcohol intake, high fat and high calorie diet, obesity, diabetes, liver functional disorders, thyroid functional disorders and nephritic syndrome.
In general, if hyperlipidemic state is continued, arteriosclerosis may be caused through the pathway that fat plaque is deposited and attached to vascular wall to induce fibrosis and then calcium is deposited thereon. Ultimately, due to such pathway the inside of artery becomes narrower.
As the therapeutic method for treatment of hyperlipidemia, a dietetic treatment has been generally and preferentially selected at present. However, if hyperlipidemic state is not improved by such a dietetic treatment, medicinal drugs such as bile acid-binding resins, nicotinic acid derivatives, pyruvic acid derivatives, probucol, etc. have been used. Recently, HMG CoA reductase inhibitors have been very commonly used as the therapeutic agent for hyperlipidemia. However, any of such medicinal drugs could not provide a satisfactory effect in clinical field as yet.
Cardiovascular system supplies oxygen, nutrients, hormones, etc. necessary for activities of individual organs and tissues and, at the same time, removes waste materials such as carbon dioxide, lactic acid, etc., as produced in respective cells, via blood circulation, thereby allowing the maintenance of normal physiological state in human body. Particularly, heart performs a function as biological circulatory pump by means of its inherent regular contractility to play a decisive role in normal activities of cardiovascular system. Therefore, the abnormality of heart function induces a metabolic disorder of substances present in human body and ultimately, induces a direct disorder of biological phenomenon. Cardiovascular diseases including congestive heart failure, coronary artery disorder, myocardial infarction, hypertension, etc., are a typical disease of adult peoples in modem society and have been raised as a serious social problem since million persons or more in advanced countries annually suffer from such diseases. Particularly, in case of persons managing modem city life, in spite of an increase of interest in prevention and treatment of such cardiovascular diseases, their morbidity is continuously on an increasing trend. Angina pectoris is a kind of cardiagra syndromes originated from transient myocardial ischemia and means a transient cardiagra attack due to coronary insufficiency.
Angina pectoris is a kind of acute coronary insufficiency. Although coronary artery has an ability of sufficiently expanding their lumen, when lumen of blood vessel is narrowed or occluded due to coronary arteriosclerosis, blood flow cannot be increased to the level necessary for cardiac muscle so that cardiac muscle may fall into ischemic state. When such ischemic state of cardiac muscle occurs for a short time, the subjective symptom which may be developed is just angina pectoris. Angina pectoris is characterized by the fact that coronary insufficiency is lasted only for a short period and the unique clinical symptom is only cardiagra attack, and has no objective symptom to make its diagnosis difficult.
At present, when angina pectoris is developed, nitroglycerine is administered via sublingual route. In this case, nitroglycerine is immediately absorbed into mucous membrane to rapidly show its pharmacological activity. Nitro-based agents such as nitroglycerine have a potent activity for dilation of peripheral artery to reduce the preload and postload of heart so that cardiac momentum can be reduced and therefore, the attack of angina pectoris may be lightened and its frequency may also be reduced. Further, nitroglycerine has an activity for dilating collateral circulation of coronary artery to increase the blood flow of coronary artery. However, since nitroglycerine has a little effect on coronary contraction and thus, has a problem that it should be administered together with calcium antagonist.
At present, in order to prevent angina pectoris nitro-based agents are internally administered. However, since such agents do not exhibit sustained activity, recently a sustained release preparation has been used. Further, ointment or tape preparations may also be used so that the active substance can be absorbed into skin. Calcium antagonists have a potent activity of reducing postload of heart and therefore, have also been used as an agent for prevention of angina pectoris. Beta-blocking agents are an agent for reducing cardiac contractility and therefore, can also be used as an agent for prevention of angina pectoris. However, in order to prevent the shift from angina pectoris to myocardial infarction numerous platelet inhibitors should be used, and further if localized stenosis is found by coronary angiography, percutaneous transluminal coronary angioplasty using balloon between aorta and coronary artery, or coronary bypath operation should be practiced. Thus, a satisfactory therapeutic method for angina pectoris has not been developed as yet to impose a heavy economical and time burden on patients.
Thus, the present inventor has assiduously and extensively examined numerous herbal medicines, which have been known as having a little side effect on human body, by combining them in various mixing ratio for a long period, in order to develop a galenic composition useful for treating hyperlipidemia and angina pectoris. As a result, he has found through numerous repeated safety and efficacy tests that a galenic composition having a specific constitution as defined in the following achieves the above-mentioned purpose, and thus completed the present invention.
SUMMARY OF THE INVENTION
The present invention relates to a galenic composition effective for prevention and treatment of hyperlipidemia, and angina pectoris due to ischemia and reperfusion. More specifically, the present invention relates to a galenic composition effective for prevention and treatment of hyperlipidemia and cardiovascular disorders, particularly, angina pectoris due to myocardial ischemia, which contains eight (8) kinds of medicinal herbs consisting of
Allium thumbergii
, trichosanthis semen, angelicae gigantis radix, salviae radix, cinnamomi ramulus, curcumae tuber, paeoniae rubrae radix and pinelliae rhizoma as the major ingredients.
The galenic composition compri
Ladas & Parry
Tate Christopher R.
LandOfFree
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