Genetic engineering process for the production of S-(+)-2,2-dime

Details Genetic engineering process for the production of S-(+)-2,2-dime Genetic engineering process for the production of S-(+)-2,2-dime

1992-07-24

1995-06-27

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

435195, 4353201, 43525233, 4352523, 536 232, C12P 1302, C12N 914, C12N 1500

Patent

active

054279348

ABSTRACT:
A genetic engineering process for the production of S-(+)-2,2-dimethylcyclopropanecarboxamide. For this purpose, a new DNA is isolated from a microorganism that codes for a stereospecific hydrolase. This DNA is then ligated in an expression vector, and a hybrid plasmid results, which is transformed into microorganisms. These microorganisms are then able to biotransform the R-(-) isomer in racemic R,S-(.+-.)-2,2-dimethylcyclopropanecarboxamide into R-(-)-2,2-dimethylcyclopropanecarboxylic acid, and optionally active S-(+)-2,2-dimethylcyclopropanecarboxamide is obtained.

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